Sickle Cell Disease and Anesthesia

After reading such a super long article (broken up into days), the inevitable conclusion was this:

“Almost a half-century after anesthetic attention was first directed to this challenging disease, the fundamental of management remains meticulous observation and vigilance of the basic principles of safe anesthesia”

Typical of most things in anesthesia and critical care (the literature on mortality improvement post ARDS suggests the same).

Perioperative Tourniquet Use in Sickle Cell Anemia

Interesting take, saying that it is safe.

Until it is rigorously tested by RCT's, it is difficult to make a conclusion.

The more we know, the more we don't know.